Explained! Nobel Prize 2023 Physiology and Medicine mRNA Base Modification and Vaccine Production
Oct 6, 2023
Nobel Prize 2023 Physiology and Medicine Explained
2023 Nobel Prize in Physiology or Medicine was jointly awarded to Katalin Karikó and Drew Weissman
“for their discoveries concerning nucleoside base modifications that enabled the development of effective mRNA vaccines against COVID-19”
Their discoveries have fundamentally changed our understanding of how mRNA interacts with our immune system and were critical for developing effective mRNA vaccines at an unprecedented rate against COVID-19 pandemic, one of the greatest threats to human health in modern times.
00:00 Introduction
00:45 Background :Vaccination before Covid 19 pandemic
02:48 Limitations of conventional vaccination strategies
03:07 mRNA vaccine Advantages and limitations
03:58 Kariko and Weissman’s Experiment
06:55 Why was Nobel Prize awarded for this discovery?
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