Gene therapy, this technology is most helpful in the treatment of diseases caused by gene defects such as cystic fibrosis, thalassemia, Parkinson’s disease, etc. Conceptualised in 1972, gene therapy involves delivery of required gene into a patient’s cell as a drug to treat disease, so that it replaces the function of the defective gene. The first attempt, although unsuccessful, was performed by Martin Cline in 1980 for treating β-thalassemia.
The first successful report of gene therapy was achieved in 1990 when, Ashanthi De Silva was treated for Adenosine Deaminase deficiency [also called Adenosine Deaminase Severe Combined Immunodeficiency (ADA-SCID)] which is an autosomal recessive metabolic disorder that causes immunodeficiency. Russia approved Neovasculgen in 2011, as a first-in-class-gene therapy for peripheral artery disease.
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https://www.biologyexams4u.com/2013/02/gene-therapy-is-it-treatment-method-for.html
https://www.biologyexams4u.com/2013/02/difference-between-gene-replacement_11.html