Explained. Nobel Prize in Chemistry 2022. What is Click Chemistry and Bioorthogonal Chemistry?

 Nobel Prize in Chemistry 2022 was awarded to three scientists 🥇

1. Barry Sharpless, Scripps Research, USA, 
2. Carolyn R. Bertozzi, Stanford University, USA and 
3. Morten Meldal, University of Copenhagen, Denmark.

Barry Sharpless pioneered the concept of click chemistry, a form of simple and reliable chemistry, where reactions occur quickly, and unwanted by-products are avoided. He also presented the first click reaction copper catalysed azide-alkyne cycloaddition.

Carolyn Bertozzi developed click reactions that work inside living organisms. Her bioorthogonal reactions take place without disrupting the normal chemistry of the cell. She developed strain induced azide-alkyne cycloaddition; a biorthogonal reaction. It is now used globally to explore cells, biomolecules and track biological processes.

This video is a summary of Nobel Prize in Chemistry 2022.

Morten Meldal independently presented the crown jewel of click chemistry: the copper catalysed azide-alkyne cycloaddition. A chemical reaction utilised in development of pharmaceuticals, for mapping DNA.

Thank You So Much