Definition: In Feed-forward activation, a metabolite
produced early in a pathway activates an enzyme that catalyze a reaction further
down the pathway
Pyruvate kinase (Step 10 enzyme) is activated by Fructose-1,6-bisphosphate
(3 rd step metabolite)
Fructose-1,6- bisphosphate is formed by the phosphorylation of
fructose-6- bisphosphate by the enzyme Phosphofructokinase (PFK). This
is the committed step or rate limiting step of Glycolysis. Excess Fructose-1,6- bisphosphate in the rate limiting step activates
the formation of final product of the reaction; pyruvate by activating the
enzyme in the final step; pyruvate kinase.
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feed forward activation
feed forward activation definition
feed forward activation example
feed forward activation glycolysis