Questions on Cancer Biology (Oncology)
1. The mutation in an
oncogene falls under which of the following classes?
1. Loss of function
mutation
2. Frame shift
mutation
3. Gain of
function mutation
4. Dominant
negative mutation
Ans: 3. Gain of function mutation
2. Which one of the following best defines an oncogene? (CSIR Life sciences,June 2016)
1. An oncogene never codes for a cell
cycle protein, which promotes cell proliferation.
2. Oncogenes are always involved in
inherited forms of cancer.
3. An oncogene codes for a protein
that prevents a cell from undergoing apoptosis.
4. An
oncogene is a dominantly expressed mutated gene that renders a cell
advantageous towards survival.
Ans: 4. An oncogene is a
dominantly expressed mutated gene that renders a cell advantageous towards
survival.
3. Which of
the following events will NOT usually lead to transformation of a normal cell into
a cancer cell?
1. Gain of
function of oncogenes
2. Loss of
function of tumor suppressors
3. Gain of function of genes involved in nucleotide
excision repair
4. Loss of
function of pro-apoptosis related Genes
Ans: 3. Gain of function of genes involved in nucleotide
excision repair
Questions on Cell signaling
4. Which one of the following statements about receptor – enzyme is FALSE? (CSIR Life sciences,June 2016)
1. A receptor – enzyme has an
extracellular ligand binding domain, a transmembrane domain and an
intracellular catalytic (enzyme) domain.
2. Many types of receptor enzymes are
found in animals.
3. The signal transduction pathways
of receptor – enzyme involve phosphorylation cascades.
4. Receptor – enzymes interact
directly with intracellular G-proteins.
Ans: 4. Receptor – enzymes interact directly with
intracellular G-proteins.
5. In the above signalling cascade,
which one of the following molecules is denoted by ‘B’? (CSIR Life sciences,June 2016)
1. STAT 5
2. SMAD 6
3. GSK3
4. SMAD 4
Ans: 4. SMAD 4
6. Cell to
cell communication is important in development of an organism. The ability of cells
to respond to a specific inductive signal is called
1. Regional
specificity of induction
2. Competence
3.
Juxtracrine signalling
4.
Instructive interaction
Ans: 2. Competence
1. Cyclic GMP
2. Diacylglycerol
3. Inositol triphosphate
4.
Phosphatidyl inositol
Ans: 4. Phosphatidyl inositol
Tags:
Cancer biology
Cell Signalling multiple choice
csir life science questions
mcq on Cancer biology