UNIT-3. Fundamental Processes (DNA replication, DNA repair and
recombination, RNA synthesis and processing, Protein synthesis and processing,
Control of gene expression at transcription and translation level)
1.
Which one of the following chemicals is a DNA intercalator? (CSIR Life sciences, Dec 2015)
1. 5-Bromouracil
2. Ethyl methane sulfonate
3. Acridine orange
4. UV
Ans: 3. Acridine orange
2. An
antibiotic that resembles the 3’end of a charged tRNA molecule is: (CSIR Life sciences, Dec 2015)
1. Streptomycin
2. Sparsomycin
3. Puromycin
4. Tetracycline
Ans: 3. Puromycin
3.α-Amanitin
is a fungal toxin which inhibits eukaryotic RNA polymerases. The three eukaryotic
RNA polymerases show differential sensitivity to this toxin. Which one of the
following order (higher to lower) is correct in respect of sensitivity towards α
- amanitin? (CSIR Life sciences,
Dec
2015)
1. RNA POL III > RNA POL II
> RNA POL I
2. RNA POL II > RNA POL III
> RNA POL I
3. RNA POL I > RNA POL III >
RNA POL II
4. RNA POL II > RNA POL I >
RNA POL III
Ans: 2. RNA POL II > RNA POL III > RNA POL I
4. In
eukaryotic replication, helicase loading occurs at all replicators during (CSIR Life sciences, Dec 2015)
1. G0 phase
2. G1 phase
3. S phase
4. G2 phase
Ans: 2. G1 phase
5.Error-free repair of
double strand breaks in DNA is accomplished by
(CSIR Life sciences, June
2016)
1. non-homologous end-joining.
2. base excision repair.
3.
homologous recombination.
4. mismatch repair.
Ans: 3. homologous
recombination.
6. RNA interference is
mediated by both siRNA and miRNA. Which one of the following statement about them is NOT
true? (CSIR Life sciences, June 2016)
1. Both siRNA and miRNA are
processed by DICER.
2. Both
siRNA and miRNA usually guide silencing of the same genetic loci from
which
they originate.
3. miRNA is a natural molecule
while siRNA is either natural or a synthetic one.
4. miRNA, but not siRNA is
processed by Drosha
Ans: 2. Both siRNA and
miRNA usually guide silencing of the same genetic loci from which they originate.
7. Which of the following are NOT
transcribed by RNA polymerase II? (CSIR Life sciences,
dec 2016)
1. miRNA and some snRNA
2. miRNA and snoRNA
3. mRNA and snoRNA
4. tRNA and 5S rRNA
8 . RNA editing, a post-transcriptional
process, is achieved with the help of guide RNA (gRNA).Which one of the
following statements about the process is NOT true? (CSIR Life sciences, dec 2016)
1. g-RNA
dependent RNA editing happens in the kinetoplast DNA
2. g-RNA is
involved in chemical modification of t-RNA
3. This process
involves insertion or deletion of uridines
4. Sequences
edited once may be re-edited using a second g-RNA
Ans: 2. g-RNA is
involved in chemical modification of t-RNA
9. Telomerase, a RNA-protein complex which completes
the replication of telomeres during DNA synthesis, is a specialized (CSIR Life sciences dec 2016)
1. RNA dependent
DNA polymerase
2. DNA dependent
DNA polymerase
3. DNA dependent
RNA polymerase
4. RNA dependent
RNA polymerase
Ans: 1. RNA
dependent DNA polymerase
10. Consider a short double-stranded linear
DNA molecule of 10 complete turns with 10.5bp/turn. The ends of the DNA
molecule are sealed together to make a relaxed circle. This relaxed circle will
have a linking number of (CSIR Life sciences dec 2016)
1. 105
2. 20.5
3. 10.0
4. 10.5
Ans: 3. 10.0
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CSIR UGC NET JRF Life sciences questions
dna replication enzymes
Molecular Biology Questions
Unit -3 Fundamental Process
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