Pedigree chart X linked Dominant Disorders

Characteristics of Sex linked Dominant Disorder:

• Both  males and females are affected; often more females than males are affected.
• Does not skip generations.
• Affected sons must have an affected mother; affected daughters must have either an affected mother or an affected father.
• Affected fathers will pass the trait on to all their daughters.
• Affected mothers (if heterozygous) will pass the trait on 1/2 of their sons and 1/2 of their daughters.

Example of Sex linked Dominant Disorder:
a) Here both males and females are affected and the typical example is X linked hypophosphotemic rickets.

b) Manifested only in females and is lethal in utero in males.

Examples include incontinenta pigmenti, focal dermal hypoplasia, and orofaciodigital syndrome.