Gene replacement therapy vs Corrective gene therapy
No
|
Gene replacement
therapy
(Gene augmentation)
|
Corrective gene
therapy
|
1
|
Addition of healthy gene
without replacing defective gene
|
Addition of healthy gene
replacing defective gene.
|
2
|
Suitable for recessive
disorders
|
Possible for dominant disorders.
|
3
|
Non-specific insertion and no
recombination event
|
Site specific insertion and
recombination event should occur.
|
4
|
Approach is not useful when the
defective gene produces a disease causing protein
|
Approach is useful when the
defective gene produces a disease causing protein or an interfering
substances.
|
5
|
The approach is more feasible
|
Extensive study is required.
|
Tags:
Corrective gene
difference between
Gene augmentation
Gene augmentation vs Corrective gene therapy
Gene replacement therapy
Gene replacement therapy vs Corrective gene therapy
gene therapy